Users with limited mobility may need to rely less on on a mouse and more on keyboards, special trackballs and input devices such as speech recognition software. Use of floating menus or small icons can be problematic for these users.
Mouse alternatives include special trackballs, "sip and puff" systems, joysticks controlled by the teeth, eye tracking devices, speech recognition input or keyboard only systems.
Generally speaking it is easier to input a keystroke rather than a mouse click. Whenever possible a tool should be available through text links, text based wizards or a keyboard shortcut (e.g. in Flash)
If mouse click tools are implemented, make the targets larger (e.g. a whole phrase) rather than smaller (e.g. only an icon or symbol).
Note: You should not necessarily implement these through hidden KEYACCESS tags. This can disrupt the normal operation of assistive devices and screen readers. Keyboard accommodations should be overtly spelled out.
Photoshop lets you enter numbers for image dimensions/resolution and tab between fields to change image size.

Anyone having difficulty using their GUI input device can be considered to have some form of mobility impairment. This includes: